反应详情

A solution of (1-biphenyl-4-yl-ethyl)-{2-[4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester (140 mg, 0.23 mmol in dioxane.HCl (10 ml) was stirred at room temperature for 1 hr. The reaction mixture was concentrated to get the residue. The residue was washed with hexane to afford 98 mg (78.4% Yield) of 2-(1-Biphenyl-4-yl-ethylamino)-1-[4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethanone hydrochloride. LCMS Purity: 93.9%. 1H NMR (CDCl3): δ 9.6 (d, 3H), 8.0 (t, 1H), 7.8-7.6 (m, 6H), 7.6-7.36 (m, 5H), 4.5 (t, 1H), 4.2-3.6 (m, 2H), 3.6-3.4 (m, 5H), 3.2-3.0 (m, 3H), 1.6 (t, 3H).

1. concentrationThe reaction mixture was concentrated
2. customto get the residue
3. washThe residue was washed with hexane