Hydrochloric Acid → HCID 66953620, compound

Participants

Reaction Steps

To a solution of 1-[4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2-(4-thiophen-3-yl-benzylamino)-ethanone (50 mg, 0.09 mmol) in ethereal.HCl (5 ml) was stirred at room temperature for 1 hr. The reaction mixture was then concentrated and the resulting residue was washed with ether to afford 36 mg (67.2%) of 1-[4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2-(4-thiophen-3-yl-benzylamino)-ethanone hydrochloride salt. LCMS Purity: 96.34%. 1H NMR (DMSO-d6): δ 9.2 (s, 1H), 8.0-7.9 (m, 2H), 7.85-7.74 (m, 2H), 7.7-7.5 (m, 6H), 4.2-4.0 (m, 4H), 3.8-3.4 (m, 5H), 3.3-3.0 (m, 3H).

Provenance & Evidence