HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → CbzNH-PEG6-CH2COOH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {2-[2-(2-{2-[2-(2-Benzyloxycarbonylamino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-acetic acid tert-butyl ester | HCID 69074603 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ammonium Hydroxide | HCID 14923 | 30% |
| Product | CbzNH-PEG6-CH2COOH | HCID 69076282 | 99% |
Reaction Steps
TFA (4 mL) was added to a solution of compound 6 (0.93 g, 1.7 mmol) in CH2Cl2 (20 mL) and the resulting solution was stirred overnight at ambient temperature. The resulting solution was concentrated in vacuo and the residue was loaded onto a silica gel gravity column (50 g) and eluted with CH2Cl2:MeOH:NH4OH(30% aqueous) 90:10:1 (v/v) to afford compound 7 as a thick colorless oil (0.83 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07276286B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-8361af2d6cb640d48c7e3793a15928f6 |
| Source note | uspto-grants-2007_10 |