Benzimidazole → HCID 58974418, compound

HRID 1178185Notes

Reaction equation

HRID 1178185 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][CH:2]=1.[CH3:10][O:11][C:12]1[CH:23]=[CH:22][C:15]([C:16]([O:18][CH2:19][CH2:20]Cl)=[O:17])=[CH:14][CH:13]=1>>[CH3:10][O:11][C:12]1[CH:23]=[CH:22][C:15]([C:16]([O:18][CH2:19][CH2:20][N:1]2[C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=[C:2]2[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:17])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 5798BenzimidazoleHCID 2287732-chloroethyl 4-methoxybenzoate

Product 1

HCID 58974418HCID 58974418, compoundYield 71%

Procedure

The procedure of Synthesis Example 10 was repeated except that benzimidazole was used instead of the 1-aza-18-crown-6, and 2-chloroethyl 4-methoxybenzoate was used instead of the 2-chloroethyl benzoate, to give 2-(2-phenyl-1H-benzimidazol-1-yl)ethyl 4-methoxybenzoate in a yield of 71%.

Workup

  1. customThe procedure of Synthesis Example 10

Sources & evidence

ORD record
ord-dfb80ab567c9463587071e3d25f3bfa6
Source dataset
uspto-grants-2007_10
Patent number
US07276324B2

Reaction notes

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