Sodium Carbonate → HCID 22320469, compound

Participants

Reaction Steps

Using the general method of Example 1 Part A, 4-chloro-3-nitroquinoline (15.0 g, 71.90 mol) was reacted with 2-chloroethylamine monohydrochloride (8.3 g, 71.90 mmol). The crude product was suspended in water (300 mL) and solid sodium carbonate was added to adjust the pH to 10. The suspension was stirred overnight and then cooled in an ice bath. The solid was then isolated by filtration and washed with chilled water to provide 15.88 g of N-(2chloroethyl)-3-nitroquinolin-4-amine as a bright yellow fluffy solid.

Provenance & Evidence