Water → N-(3,5-dimethoxyphenyl)acetamide

Participants

Reaction Steps

A solution of 15.3 g of 3,5-dimethoxyaniline and 57.5 ml of acetic anhydride in 40 ml of anhydrous pyridine is heated at reflux for 1 hour. The reaction mixture is then cooled and poured into 350 ml of water. The precipitate formed is suspended in 20% aqueous Na2CO3 solution and is then filtered off using a Buchner funnel, washed with water and dried under a phosphoric vacuum. A precipitate of 14.5 g of the expected product is obtained in the form of a white amorphous solid.

Provenance & Evidence