Acetic Anhydride → HCID 131726613, compound

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Reaction Steps

To a solution of 0.5 mmol of the compound of Example 4 in 3 ml of anhydrous pyridine there are added 1.1 equivalents of succinic anhydride and 1 mg of dimethylaminopyridine. Stir for 2 days in the dark and at ambient temperature, then add 25 ml of acetic anhydride at −15° C. and stir for 1.5 hours before concentrating under reduced pressure. Chromatography over silica gel (dichloromethane/acetic acid: 99/1) allows the expected product to be isolated.

Provenance & Evidence