Acetic Anhydride → HCID 72994532, compound

HRID 1178308Notes

Reaction equation

HRID 1178308 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[OH:8][C@@H:9]1[C:14]2=[C:15]3[C:24](=[C:25]([O:27][CH3:28])[CH:26]=[C:13]2[O:12][C:11]([CH3:36])([CH3:35])[C@@H:10]1[OH:37])[C:23](=[O:29])[C:22]1[C:17](=[CH:18][CH:19]=[C:20]2[CH:33]=[CH:32][CH:31]=[CH:30][C:21]2=1)[N:16]3[CH3:34]>N1C=CC=CC=1>[C:1]([O:37][CH:10]1[C:11]([CH3:35])([CH3:36])[O:12][C:13]2[C:14](=[C:15]3[C:24](=[C:25]([O:27][CH3:28])[CH:26]=2)[C:23](=[O:29])[C:22]2[C:17](=[CH:18][CH:19]=[C:20]4[CH:33]=[CH:32][CH:31]=[CH:30][C:21]4=2)[N:16]3[CH3:34])[CH:9]1[OH:8])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 11697098HCID 11697098, compound

Product 1

HCID 72994532HCID 72994532, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2.2 mmol of acetic anhydride are added to a solution, cooled to 0° C., of 2 mmol of the compound of Example 4 in 5 ml of anhydrous pyridine. After stirring at ambient temperature for 3 hours, the reaction mixture is concentrated under reduced pressure. Chromatography over silica gel (dichloromethane, and then dichloromethane/methanol: 99/1) allows the expected product to be isolated.

Workup

  1. concentrationthe reaction mixture is concentrated under reduced pressure
  2. customto be isolated

Sources & evidence

ORD record
ord-bbeabb9de1a4461a84a51b5423b9ab24
Source dataset
uspto-grants-2007_10
Patent number
US07276512B2

Reaction notes

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