Acetic Anhydride → HCID 131726619, compound

HRID 1178310Notes

Reaction equation

HRID 1178310 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[C:8]1(/[CH:14]=[CH:15]/[C:16]([O:18][CH:19]2[C:36]([CH3:38])([CH3:37])[O:35][C:34]3[C:21](=[C:22]4[C:31](=[C:32]([O:39][CH3:40])[CH:33]=3)[C:30](=[O:41])[C:29]3[C:24](=[CH:25][CH:26]=[C:27]5[CH:45]=[CH:44][CH:43]=[CH:42][C:28]5=3)[N:23]4[CH3:46])[CH:20]2[OH:47])=[O:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>N1C=CC=CC=1>[C:8]1(/[CH:14]=[CH:15]/[C:16]([O:18][CH:19]2[C:36]([CH3:38])([CH3:37])[O:35][C:34]3[C:21](=[C:22]4[C:31](=[C:32]([O:39][CH3:40])[CH:33]=3)[C:30](=[O:41])[C:29]3[C:24](=[CH:25][CH:26]=[C:27]5[CH:45]=[CH:44][CH:43]=[CH:42][C:28]5=3)[N:23]4[CH3:46])[CH:20]2[O:47][C:1](=[O:3])[CH3:2])=[O:17])[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 131726618HCID 131726618, compound

Product 1

HCID 131726619HCID 131726619, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

31 mmol of acetic anhydride are added to a previously cooled solution of 0.18 mmol of the compound of Example 35 in 3 ml of pyridine. After stirring at ambient temperature for 3 days, the reaction mixture is evaporated under reduced pressure. Chromatography over silica gel (cyclohexane/acetone: 94/6) allows the expected product to be isolated.

Workup

  1. customthe reaction mixture is evaporated under reduced pressure
  2. customto be isolated

Sources & evidence

ORD record
ord-1e8d633553ed4bb0a0ea5200d6dc7c35
Source dataset
uspto-grants-2007_10
Patent number
US07276512B2

Reaction notes

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