Ethanol → 72954-97-3

Participants

Reaction Steps

tert-Butoxycarbonylamino-(3,4-dichlorophenyl)-acetic acid (900 g) was dissolved in ethanol (4.5 L). Thionyl chloride (417 mL) was added to the resultant solution, followed by refluxing for one hour. The reaction mixture was left to cool to room temperature. The solvent was evaporated under reduced pressure. Ethyl acetate was added to the residue, followed by filtration and drying, to thereby give the title compound (286 g, 35%, 3 steps).

Provenance & Evidence