Sodium periodate → HCID 58696353, compound

Participants

Reaction Steps

tert-Butyl[1-{[(2-chloro-2,2-difluoroacetyl)-methylamino]-methyl}-1-(3,4-dichlorophenyl)-3,4-dihydroxybutyl]methylcarbamate (323 mg) was dissolved in a mixture solvent of tetrahydrofuran (3 mL) and water (3 mL). Sodium periodate (266 mg) was added thereto, and the mixture was stirred for 1.5 hours at room temperature. The reaction mixture was concentrated under reduced pressure, and water was added to the residue, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate anhydrate, and concentrated under reduced pressure, to thereby give the title compound (291 mg, 96%). The compound was used in the next step without further purification.

Provenance & Evidence