Dichloromethane → HCID 12463469, compound

Participants

Reaction Steps

Valeraldehyde (2.5 g, 29.02 mmol) and (carbethoxyethylidene)triphenyl phosphorane (12.54 g, 34.83 mmol) in methylene chloride was refluxed for 7 hours. After cooling to room temperature, the solvent was evaporated. The residue was purified through flash chromatography on silica gel (EtOAc:Hexanes=2:98) to give 4.2 g as colorless oil in 85% yield. 1HNMR (CD3Cl): δ 0.920 (t, J=7.4 Hz, 3H), 1.30 (m, 7H), 1.81 (s, 3H), 2.19 (t, J=7.4 Hz, 2H), 4.18 (q, J=7.4 Hz, 2H), 6.75 (t, J=7.4 Hz, 1H).

Provenance & Evidence