Bromine → HCID 21964198, compound

HRID 1178572Notes

Reaction equation

HRID 1178572 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=[O:25])[CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:12]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Br:26]Br>C(O)(=O)C>[BrH:26].[Br:26][CH:10]([C:11]1[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:12]=1)[C:9]([C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH3:8])[CH:5]=1)=[O:25]

Participants

4

Reactant 2

HCID 24408BromineHCID 219642482-[2-(Benzyloxy)pyridin-4-yl]-1-(3,5-dimethylphenyl)ethan-1-one

Product 1

HCID 21964198HCID 21964198, compoundYield 196%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1-(3,5-Dimethylphenyl)-2-(2-phenylmethyloxy-4-pyridyl)ethanone (3.3 g, 10 mmol) was dissolved in acetic acid (10 mL) and bromine (0.51 mL, 10 mmol) was added to the solution and stirred at room temperature for 30 minutes. The precipitated crude crystals were collected by filtration and washed with diethyl ether to obtain 4.8 g of the title compound (9.8 mmol, yield 98%).

Workup

  1. customThe precipitated crude crystals
  2. filtrationwere collected by filtration
  3. washwashed with diethyl ether

Sources & evidence

ORD record
ord-e89cfc11d0014f9aa73b03ccb504ad36
Source dataset
uspto-grants-2007_10
Patent number
US07276527B2

Reaction notes

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