3-Pyridyl isothiocyanate → HCID 178493489, compound

Participants

Reaction Conditions

Reaction Steps

To compound 11 (6.76 g, 24.1 mmol) in ethyl acetate (18 mL) is added 3-pyridylisothiocyanate (3.9 ml-, 36.2 mmol) at room temperature. The reaction is then heated to 60° C. and stirred for 4 hours. More ethyl acetate is added (12 mL) and the reaction is stirred for an additional 4 hours. The reaction is cooled to room temperature and filtered. The solids are washed with ethyl ether twice and with methanol once. The solids are further dried in vacuo to obtain compound 12 (5.88 g, 59%). 1H NMR (d6 DMSO): δ 10.12 (1H, br. s), 8.46 (1H, d, J=2.4 Hz), 8.36 (1H, d, J=5.2 Hz), 7.71 (1H, d, J=9.0 Hz), 7.37 (1H, dd, J=9.0, 5.2 Hz), 6.27 (2H, s), 4.25 (2H, s), 3.81 (6H, s), 3.77 (3H, s).

Provenance & Evidence