Indole → HCID 23118667, 화합물

HRID 1178740노트

반응식

[CH:1]1[C:14]2[C:5](=[N:6][CH:7]=[C:8]3[C:13]=2[CH:12]=[CH:11][CH:10]=[CH:9]3)[CH:4]=[CH:3][CH:2]=1.[CH:15]1([CH2:20][CH2:21][C:22](Cl)=[O:23])[CH2:19][CH2:18][CH2:17][CH2:16]1.[NH:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[CH:26]1>>[CH:15]1([CH2:20][CH2:21][C:22]([N:6]2[CH:7]([C:27]3[C:28]4[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=4)[NH:25][CH:26]=3)[C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]2=3)=[O:23])[CH2:19][CH2:18][CH2:17][CH2:16]1

참가 물질

반응물 3

HCID 798Indole

HCID 9189Phenanthridine

HCID 660393-Cyclopentylpropionyl chloride

생성물 1

HCID 23118667HCID 23118667, 화합물

실험 절차

3-Cyclopentyl-1-[6-(1H-indol-3-yl)-6H-phenanthridin-5-yl]-propan-1-one was prepared from phenanthridine, 3-cyclopentylpropionyl chloride, and indole according to GP 2. Yield, 5%. 1H-NMR (CD3OD): δ=0.80-0.99 (m, 2H), 1.27-1.70 (m, 9H), 2.60 (“t”, J≈7 Hz, 2H), 6.08 (s, 1H), 6.98-7.04 (m, 2H), 7.07 (td, J≈7 Hz, J=1.3 Hz, 1H), 7.12 (td, J=7.9 Hz, J=1.4 Hz, 1H), 7.21 (“d”, J≈7.4 Hz, 1H), 7.26 (“t”, J≈7.6 Hz, 1H), 7.36-7.42 (m, 3H), 7.45-7.52 (m, 1H), 7.78 (d, J=7.3 Hz, 1H), 7.90 (d, J=7.7 Hz, 1H), 7.97 (d, J=7.7 Hz, 1H); (+)-ESI-MS: m/z=421 [M+H]+, 304 [M-indole+H]+, 180.

후처리

customYield

출처 및 근거

ORD 기록: ord-a47caa86808947a5a9dfb334e1f599a6
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07276606B2

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