Citric Acid → HCID 23118686, compound

Participants

Reaction Steps

To a solution of (5-acetyl-5,6-dihydro-phenanthridin-6-yl)-acetic acid methyl ester (210 mg, 0.71 mmol) dissolved in a mixture of dioxane (10 mL) and water (10 mL), LiOH×H2O (42 mg, 1 mmol) was added. The solution was allowed to stir at r.t. for 4 h. Citric acid (5% solution in water) was added and the mixture was extracted with ethyl acetate. The organic phase was washed with citric acid (2×), water (1×), and brine (1×). After drying over MgSO4, the solvent was removed in vacuo to give a colourless oil that solidified on standing ar r.t. Yield, 70%. (+)-ESI-MS: m/z=282 [M+H]+, 240, 222, 180.

Provenance & Evidence