3-Bromothiophene → HCID 58975533, compound

Participants

Reaction Steps

To a solution of 4A (25 mg, 0.043 mmol) in degas sed THF (2 mL) was added tetrakis(triphenylphosphine)palladium (10 mg, 0.009 mmol), K2C3 (18 mg, 0.13 mmol), and 3-bromothiophene (21 mg, 0.13 mmol). The resulting mixture was heated at 70° for 16 h under argon. After cooling to RT, the mixture was filtered through Celite®, rinsing with CH2Cl2. The filtrate was evaporated under vacuum and the resulting residue was chromatographed on silica gel eluted with EtOAc in hex ane to obtain the title compound (14.5 mg, somewhat impure).

Provenance & Evidence