Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium 3-nitrobenzenesulfonate | HCID 31389 | — |
| Reactant | 2-Bromo-4-fluoroaniline | HCID 242873 | — |
| Solvent | Glycerol | HCID 753 | — |
| Product | 8-Bromo-6-fluoroquinoline | HCID 21271249 | 416.7% |
Reaction Steps
To a mixture of 7.0 g of 2-bromo-4-fluoro-aniline, 7.0 g of glycerol and 13.0 g of m-nitrobenzene sulfonic acid sodium salt, 20 ml of 70% sulfuric acid was added drop by drop. The reaction temperature was raised to 150° C. for 4 hr. The mixture was cooled, poured on water neutralized with NaOH and the formed precipitate was filtered to yield 34.7 g of 6-fluoro-8-bromo-quinoline. MS (ES) m/z (relative intensity): 227 (M++H, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07276603B2 |
|---|
| Source dataset | uspto-grants-2007_10 |
|---|
| ORD ID | ord-8195d11e4aab4041a7fd5e609d76dbfb |
|---|
| Source note | uspto-grants-2007_10 |
|---|
