Hydrazine → HCID 11683136, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-((1R,3S)-3-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-3-phenylcyclopentyl)isoindoline-1,3-dione (113 mg), available from Example 7, in toluene (0.83 mL) was added anhydrous hydrazine (66 μL), and the reaction mixture was heated at 80° C. for 12 h. The precipitate was removed by filtration, and the filtrate was evaporated in vacuo to give the title compound (80 mg). The 1H NMR data is identical to that of its (1S,3R) isomer shown in Example 6. HRMS m/z calcd for C21H22F6NO (M+H)+ 418.1607. found 546.1619.

Provenance & Evidence