HCID 69422567, compound → HCID 69419848, compound

Participants

Reaction Steps

cis-1-[(tert-Butyloxycarbonyl)methylamino]-3-(4-methylpiperidin-1-yl)cyclopentane hydrochloride (394.5 mg, 1.19 mmol) was dissolved in hydrogen chloride in methanol [prepared by cautious addition of acetyl chloride (2 ml) to methanol (20 ml)]. The resulting solution was stirred at room temperature for 3 hours, concentrated in vacuo to give an oil which was crystalized from methanol-ethyl acetate. The solid was collected under suction, washed with ethyl acetate and dried in vacuo to give the title compound (295.3 mg, 93%) as a white solid; δH (400 MHz, CD3OD) 1.02 (3H, d, J 6.4 Hz), 1.51-1.63 (2H, m), 1.73 (1H, m), 1.92-2.29 (7H, m), 2.67 (1H, m), 2.73 (3H, s), 2.98 (2H, m), 3.62 (4H, m); m/z (ES+) 197 ([M+H]+, 100%), 166.

Provenance & Evidence