Trimethylsilyl iodide → HCID 68527755, compound

Participants

Reaction Steps

To a solution of ethyl 3-[(tert-butylamino)carbonyl]-3-cyclohexyl-8-azabicyclo[3.2.1]octane-8-carboxylate (1-8) (1.00 g, 2.74 mmol) in DCM (20.0 mL) was slowly added iodotrimethylsilane (2.20 g, 11.0 mmol). The mixture was stirred at room temperature overnight. The solvents were removed under vacuum and the solid was washed with ether (2×5 mL) to give (1-9 as a yellow solid.

Provenance & Evidence