反应详情

Shake a mixture of o-anisidine (5.0 g, 41 mmol) and rhodium on carbon (5% Rh; 5.0 g) in AcOH (65 mL) under H2 (60 psig) at 60° C. for 6 h. Filter the reaction mixture and rotary evaporate the filtrate (75° C.). Dissolve this material in CHCl3 (100 mL) and basify with satd aq NaHCO3 (50 mL). Dry the organic layer (Na2SO4) and rotary evaporate (40° C.) to yield 1.20 g of 2-methoxy-cyclohexylamine as a yellow oil.

1. filtrationFilter the reaction mixture
2. customrotary evaporate the filtrate (75° C.)
3. dissolutionDissolve this material in CHCl3 (100 mL)
4. dry with materialDry the organic layer (Na2SO4)
5. customrotary evaporate (40° C.)