Hydroxyamine hydrochloride → HCID 86594056, compound

Participants

Reaction Steps

4-Dimethylamino-4-phenylcyclohexanone (10 g) and hydroxylamine hydrochloride (4.8 g) were dissolved in absolute ethanol (120 ml), basic ion exchanger Amberlyst A 21 (30.7 g) was added to the solution, and stirring was carried out overnight at RT. The ion exchanger was filtered off and washed with ethanol (3×50 ml) on the frit. The ethanol was removed in vacuo and the residue was adjusted to pH 11 with 5M NaOH, diluted with water and extracted with ethyl acetate (4×30 ml). The combined extracts were dried with Na2SO4 and concentrated. 11 g of 4-dimethylamino-4-phenyl-cyclohexanone oxime were obtained.

Provenance & Evidence