2-Fluorobenzonitrile → HCID 67210811, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of rhodium acetate (32 mg, 72 μmol) and 2-fluorobenzonitrile (2.31 ml; 22 mmol) in perfluorobenzene (5 ml) is treated at 60° C. dropwise by a solution of diazocyclohexanedione (obtained in Stage 66.1; 1 g; 7.24 mmol) in 5 ml of perfluorobenzene. The reaction medium is maintained at 60° C. until exhaustion of the release of nitrogen (1 hour; TLC on SiO2: 2% MeOH/CH2Cl2). After cooling down to ambient temperature and filtration, the solvent of the filtrate is evaporated. The residue is purified by chromatography (SiO2: AcOEt/heptane: 1/1) in order to produce a light yellow powder.

Provenance & Evidence