HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-benzo[e][1,3]oxazin-2-one → N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-2-(2-oxo-2H-benzo[e][1,3]oxazin-4-ylamino)-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-benzo[e][1,3]oxazin-2-one | HCID 11309887 | — |
| Reactant | 2-amino-N-(-4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexylpropionamide bis hydrochloride salt | HCID 22566339 | — |
| Product | N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-2-(2-oxo-2H-benzo[e][1,3]oxazin-4-ylamino)-propionamide | HCID 10094619 | — |
Reaction Steps
The title compound was prepared starting from 4-chloro-benzo[e][1,3]oxazin-2-one (prepared from benzo [e][1,3]oxazin-2,4-dione and PCl5 in refluxing toluene) and 2-amino-N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-propionamide bis hydrochloride salt according to the procedure from Example 81. MS, m/z 438=M+1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279472B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-b49251f03bec424b94a00b185cc6d601 |
| Source note | uspto-grants-2007_10 |