Hydrazine hydrate (1:1) → 4-Hydrazino-6-(4-methylpiperazin-1-yl)pyrimidine

Participants

Reaction Steps

4-Chloro-6-(4-methyl-piperazin-1-yl)-pyrimidine, (200 mg, 0.94 mmol), and hydrazine hydrate, (200 μl, 4 mmol), were heated to 180° for 6 min in a Personal Chemistry Microwave. The solvent was evaporated affording [6-(4-Methyl-piperazin-1-yl)-pyrimidin-4-yl]-hydrazine as yellow brown crystals which were used without further purification.

Provenance & Evidence