Hydrogen Peroxide → HCID 58976985, compound

Participants

Reaction Steps

To a stirred solution of 5-(5-amino-3-phenylamino-[1,2,4]triazol-1-yl)-2-methoxy-benzonitrile (20 mg, 0.065 mMol) and K2CO3 (2 mg) in DMSO (0.3 mL), at r.t., add a solution of 30% aq. H2O2, (0.3 mL). After 1 h, add additional 30% aq. H2O2 (0.15 mL). After 40 min, water is added along with 5% aq. Na2CO3 and the mixture is stirred for several minutes. The solid was collected and rinsed with several portions of water and dried in vacuo to provide a white solid (18 mg, 0.055 mMol, 85% yield). 1H NMR 500 MHz (dmso) 8.82 (s, 1H), 7.93 (d, 1H), 7.71 (br s, 1H), 7.63 (dd, 1H), 7.60 (br s, 1H), 7.52 (d, 2H), 7.25 (d, 1H), 7.19 (t, 2H), 6.75 (t, 1H), 6.28 (br s, 2H), 3.93 (s, 3H) ppm. LC/MS: Rt=2.27 min, (M+H)=325.2

Provenance & Evidence