反应详情

温度

100 °C

A mixture of methyl 4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (0.2 g, 0.91 mmol) and 4-fluorobenzyl amine (Aldrich, 0.31 mL, 2.72 mmol) in absolute ethanol (5 mL) was heated to 100° C. for 6 hours. A thick paste formed. The reaction was diluted with water and the solids collected. The crude material was purified by preparative reverse phase HPLC eluting with a gradient of 5-95% acetonitrile/water (0.1% TFA). The product precipitated from the column fractions was collected to afford the desired product as a white solid.

1. customA thick paste formed
2. customthe solids collected
3. customThe crude material was purified by preparative reverse phase HPLC
4. washeluting with a gradient of 5-95% acetonitrile/water (0.1% TFA)
5. customThe product precipitated from the column fractions
6. customwas collected