HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → Methanesulfonamide, N-[2-[(2-cyano-3-pyridinyl)amino]ethyl]-N-methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Cyano-3-fluoropyridine | HCID 7060408 | — |
| Reactant | HCID 87801618 | HCID 87801618 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methanesulfonamide, N-[2-[(2-cyano-3-pyridinyl)amino]ethyl]-N-methyl- | HCID 58977993 | — |
Reaction Steps
In a manner similar to that described for Example 2, 2-[methyl(methylsulfonyl)amino]ethanaminium chloride (4 g, 25.4 mmol) was dissolved in DMSO (20 mL) and treated with 3-fluoro-2-cyanopyridine (2.5 g, 21.2 mmol) and Hunig's base (4.4 mL, 25.4 mmol) and heated to 90 degrees under pressure. The product was isolated as an oily off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279487B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-496c38a8eb7642d690a3c0936ec17563 |
| Source note | uspto-grants-2007_10 |