Hydrochloric Acid → HCID 69373683, compound

Participants

Reaction Steps

In a manner similar to that described for Example 2, N-{2-[(2-cyanopyridin-3-yl)amino]ethyl}-N-methylmethanesulfonamide was treated with MeOH, HCl and water to give methyl 3-({2-[methyl(methylsulfonyl)amino]ethyl}amino)pyridine-2-carboxylate after aqueous workup. The crude product was then treated with NaH and methyl 3-chloro-3-oxopropionate as described in Example 2 and after aqueous workup the crude methyl 4-hydroxy-1-{2-[methyl(methylsulfonyl)amino]ethyl}-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate was obtained as a pink foam. A portion of the material was crystallized from EtOH to give the product as light brown crystals.

Provenance & Evidence