4-Fluorobenzylamine → HCID 54680470, compound

HRID 1179312Notes

Reaction equation

HRID 1179312 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5]([CH2:12][CH2:13][N:14]([CH3:19])[S:15]([CH3:18])(=[O:17])=[O:16])[C:4](=[O:20])[C:3]=1[C:21](OC)=[O:22].[F:25][C:26]1[CH:33]=[CH:32][C:29]([CH2:30][NH2:31])=[CH:28][CH:27]=1>CCO>[F:25][C:26]1[CH:33]=[CH:32][C:29]([CH2:30][NH:31][C:21]([C:3]2[C:4](=[O:20])[N:5]([CH2:12][CH2:13][N:14]([CH3:19])[S:15]([CH3:18])(=[O:16])=[O:17])[C:6]3[C:11]([C:2]=2[OH:1])=[N:10][CH:9]=[CH:8][CH:7]=3)=[O:22])=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 673264-FluorobenzylamineHCID 58978009HCID 58978009, compound

Product 1

HCID 54680470HCID 54680470, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner similar to that described in Example 2, methyl 4-hydroxy-1-{2-[methyl(methylsulfonyl)amino]ethyl}-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate was dissolved in EtOH and treated with 4-fluorobenzylamine at reflux. After cooling the product fell out of solution and was collected. The crude was dissolved in CHCl3, washed with 10% KHSO4 solution, the organic was dried over MgSO4, filtered and evaporated to give the product as a white foam.

Workup

  1. temperatureat reflux
  2. temperatureAfter cooling the product
  3. customwas collected
  4. dissolutionThe crude was dissolved in CHCl3
  5. washwashed with 10% KHSO4 solution
  6. dry with materialthe organic was dried over MgSO4
  7. filtrationfiltered
  8. customevaporated

Sources & evidence

ORD record
ord-cde5ff58cefa4d969340f51321d35164
Source dataset
uspto-grants-2007_10
Patent number
US07279487B2

Reaction notes

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