Dimethylcarbamoyl Chloride → N-[4-fluoro-2-(methylsulfonyl)benzyl]-1-{2-[[(dimethylamino)carbonyl](methyl)-amino]ethyl}-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Dimethylcarbamoyl Chloride	HCID 6598	—
Reactant	N-[4-fluoro-2-(methylsulfonyl)benzyl]-4-hydroxy-1-[2-(methylamino)ethyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide	HCID 58978004	—
Product	N-[4-fluoro-2-(methylsulfonyl)benzyl]-1-{2-[[(dimethylamino)carbonyl](methyl)-amino]ethyl}-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide	HCID 54721532	—

Reaction Steps

The compound was prepared in a manner similar to that described for Example 22, using N-[4-fluoro-2-(methylsulfonyl)benzyl]-4-hydroxy-1-[2-(methylamino)ethyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide and N,N-dimethylcarbamoyl chloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07279487B2
Source dataset	uspto-grants-2007_10
ORD ID	ord-50b542aa6aa843399cb648651c5cea12
Source note	uspto-grants-2007_10