HCID 10049155, compound → HCID 10071379, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 29.7 mg of 1-[1-[1-(3-Chloro-2-thenoyl)piperidin-4-yl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one and 7 mg of lithium aluminum hydride in 1 ml of THF was stirred at 0° C. for 2 h and then quenched with Na2SO4—10H2O. The mixture was stirred overnight and the insoluble material was removed by filtration. The filtrate was concentrated and purified with PTLC (CHCl3/MeOH/28% aqueous NH3=120/10/1) to give 11.0 mg of the target compound as a colorless solid.

Provenance & Evidence