2-Aminobenzimidazole → N1-(1H-benzo[d]imidazol-2-yl)propane-1,3-diamine

Participants

Reaction Steps

3-{[(2-aminoanilino)carbothioyl]amino}propylcarbamate (ESI-MS; [M+H+]: 325.15), which was then converted with HgO/cat. S into the corresponding aminobenzimidazole (6.4 g; ESI-MS; [M+H+]: 291.15). After removal of the Boc group using TFA, the crude product obtained was boiled in CH3OH with addition of active carbon, filtered, evaporated and crystallized from CH3OH/methyl t-butyl ether; 6 g of beige solid; ESI-MS; [M+H+]: 191.1.

Provenance & Evidence