Hydrochloric Acid → HCID 44454980, compound

Participants

Reaction Steps

0.53 g (10 mmol) of the t-butyl ester from Example I was dissolved in a mixture of 10 ml of CH2Cl2, 5 ml of glacial acetic acid and 0.25 ml of water, and the solution was treated with 7 ml of 4 N HCl in dioxane and stirred at room temperature overnight. Toward the end, the solvent was distilled off in vacuo with addition of toluene and the residue was purified by column chromatography (eluent: CH2Cl2/MeOH/50% strength acetic acid, 45/5/1). After stripping off the solvent and digesting with ether, 0.42 g (84%) of amorphous powder remained; FAB-MS [M−H+]: 498.

Provenance & Evidence