[5-(2-tert-Butoxy-2-oxoethyl)-1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]acetic acid → tert-Butyl {2-[2-({4-[(1H-benzimidazol-2-ylamino)methyl]-cyclohexyl}amino)-2-oxoethyl]-1-oxo-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acetate

Participants

Reaction Steps

0.6 g (1.8 mmol) of compound 3 and 0.57 g (1.8 mmol) of compound 6 were reacted analogously to Example I and the reaction product was purified by means of preparative thick-layer chromatography (eluent: CH2Cl2/MeOH/ammonia, 45/5/0.2); 0.45 g of white amorphous powder; ESI-MS [M+H+]: 560.

Provenance & Evidence