HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-({[4-({[5-(Carboxymethyl)-1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]acetyl}amino)cyclohexyl]methyl}amino)-1H-benzimidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl {2-[2-({4-[(1H-benzimidazol-2-ylamino)methyl]-cyclohexyl}amino)-2-oxoethyl]-1-oxo-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acetate | HCID 86591658 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-({[4-({[5-(Carboxymethyl)-1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]acetyl}amino)cyclohexyl]methyl}amino)-1H-benzimidazole hydrochloride | HCID 86591659 | — |
Reaction Steps
Analogously to Example II, the t-butyl ester (Example V) in glacial acetic acid was cleaved using 4N HCl in dioxane. After freeze-drying, 0.45 g of white amorphous hydrochloride remained; ESI-MS [M+H+]: 504.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279468B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-3c061b41f8a44b4c806401cb8b9dd7d3 |
| Source note | uspto-grants-2007_10 |