Methyl morpholine oxide → tert-Butyl 4-formylpiperidine-1-carboxylate

Participants

Reaction Steps

To a mixture of the product of Example 1 (23.1 g), 4-methylmorpholine N-oxide (NMO, 18.9 g) and 4A molecular sieves (53.5 g) in DCM (214 mL) was added tetrapropylammonium perruthenate (TPAP, 1.9 g) portion-wise at room temperature. The reaction mixture was stirred at room temperature for 1 h and filtered through a pad of silica gel. Evaporation of solvent gave the title compound as a light yellow oil (15.0 g).

Provenance & Evidence