HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1179349Generated: November 2, 2026
Water → 4-[4-(Hydroxymethyl)piperidin-1-yl]benzaldehyde
https://huagongshe.com/reaction/1179349
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | 4-Piperidinemethanol | HCID 420771 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[4-(Hydroxymethyl)piperidin-1-yl]benzaldehyde | HCID 18526165 | — |
Reaction Steps
A suspension of 4-fluorobenzaldehyde (4.3 mL), 4-hydroxymethylpiperidine (4.8 g), and cesium carbonate (26 g) in DMF (80 mL) was heated to 100° C. for 24 h and cooled to room temperature. Water (400 mL) was added, and the resulting precipitate was collected by filtration to give the title compound as a tan amorphous powder (4.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07279491B2 |
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| Source dataset | uspto-grants-2007_10 |
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| ORD ID | ord-eece5a71b93c41c7b2457cced25857be |
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| Source note | uspto-grants-2007_10 |
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