HCID 2726119, compound → HCID 16793124, compound

HRID 1179435Notes

Reaction equation

HRID 1179435 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:21])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)=[CH:5][CH:4]=1>[Pd].CCO>[NH2:18][C:15]1[CH:14]=[CH:13][C:12]([CH2:11][C:10]([NH:9][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[O:21])=[CH:17][CH:16]=1

Participants

4

Reactant 1

HCID 2726119HCID 2726119, compound

Product 1

HCID 16793124HCID 16793124, compoundYield 95.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of N-(4-Methoxy-phenyl)-2-(4-nitro-phenyl)-acetamide (859 mg, 3 mmol), 5% Pd on C (16 mg) and EtOH (20 mL) was stirred under a hydrogen atmosphere (1 atm) for 5 hr. Filtration of the catalyst and evaporation of the solvent afforded 2-(4-Amino-phenyl)-N-(4-methoxy-phenyl)-acetamide (732 mg, 95%).

Workup

  1. filtrationFiltration of the catalyst and evaporation of the solvent

Sources & evidence

ORD record
ord-f8e75be0a0e9406096fdea4c3a3bbf7d
Source dataset
uspto-grants-2007_10
Patent number
US07279498B2

Reaction notes

Loading…