HCID 10967937, compound → HCID 10075427, compound

HRID 1179441Notes

Reaction equation

HRID 1179441 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@:4]1([CH3:18])[C@H:9]2[O:10][C@H:8]2[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1.[F:21][C:22]([F:37])([F:36])[C:23]1[CH:28]=[CH:27][C:26]([NH:29][CH2:30][C:31]2[NH:32][CH:33]=[CH:34][N:35]=2)=[CH:25][CH:24]=1>>[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@:4]1([CH3:18])[C@@H:9]([OH:10])[C@H:8]([N:29]([C:26]2[CH:25]=[CH:24][C:23]([C:22]([F:37])([F:36])[F:21])=[CH:28][CH:27]=2)[CH2:30][C:31]2[NH:35][CH:34]=[CH:33][N:32]=2)[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1

Participants

3

Reactant 2

HCID 10967937HCID 10967937, compoundHCID 54976355HCID 54976355, compound

Product 1

HCID 10075427HCID 10075427, compoundYield 22.2%

Procedure

The title compound (146 mg, 22%) was prepared using (2S,3S,4S)-3,4-dihydro-2-dimethoxymethyl-3,4-epoxy-2-methyl-6-nitro-2H-1-benzopyran (356 mg, 1.26 mmol) and 4-trifluoromethylphenyl-1H-imidazol-2-ylmethylamine (305 mg, 1.26 mmol), according to the same procedure used for the preparation of example 0.1 above.

Workup

  1. customused for the preparation of example 0.1 above

Sources & evidence

ORD record
ord-00917edfbf10485782627d84fd410bc8
Source dataset
uspto-grants-2007_10
Patent number
US07279497B2

Reaction notes

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