HCID 10967937, compound → HCID 10457951, compound

HRID 1179445Notes

Reaction equation

HRID 1179445 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@:4]1([CH3:18])[C@H:9]2[O:10][C@H:8]2[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1.[CH3:21][C:22]1[CH:27]=[C:26]([CH3:28])[CH:25]=[CH:24][C:23]=1[NH:29][CH2:30][C:31]1[NH:32][CH:33]=[CH:34][N:35]=1>>[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@:4]1([CH3:18])[C@@H:9]([OH:10])[C@H:8]([N:29]([C:23]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:22]=2[CH3:21])[CH2:30][C:31]2[NH:35][CH:34]=[CH:33][N:32]=2)[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1

Participants

3

Reactant 2

HCID 10967937HCID 10967937, compoundHCID 61557693HCID 61557693, compound

Product 1

HCID 10457951HCID 10457951, compoundYield 33.7%

Procedure

The title compound (231 mg, 33%) was prepared using (2S,3S,4S)-3,4-dihydro-2-dimethoxymethyl-3,4-epoxy-2-methyl-6-nitro-2H-1-benzopyran (400 mg, 1.42 mmol) and 2,4-dimethylphenyl-1H-imidazol-2-ylmethylamine (287 mg, 1.42 mmol), according to the same procedure used for the preparation of example 1 above.

Workup

  1. customused for the preparation of example 1 above

Sources & evidence

ORD record
ord-4574e2f56d504d1f91958b360dc72cd7
Source dataset
uspto-grants-2007_10
Patent number
US07279497B2

Reaction notes

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