HCID 11065861, compound → HCID 67420902, compound

HRID 1179448Notes

Reaction equation

HRID 1179448 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@@H:9]2[O:10][C@@H:8]2[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1.[CH3:21][C:22]1[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:23]=1[NH:29][CH2:30][C:31]1[NH:32][CH:33]=[CH:34][N:35]=1>>[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@H:9]([OH:10])[C@@H:8]([N:29]([C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([CH3:28])[C:22]=2[CH3:21])[CH2:30][C:31]2[NH:35][CH:34]=[CH:33][N:32]=2)[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1

Participants

3

Reactant 2

HCID 11065861HCID 11065861, compoundHCID 57824265HCID 57824265, compound

Product 1

HCID 67420902HCID 67420902, compoundYield 49%

Procedure

The title compound (416 mg, 49%) was prepared using (2R,3R,4R)-3,4-dihydro-2-dimethoxymethyl-3,4-epoxy-2-methyl-6-nitro-2H-1-benzopyran (500 mg, 1.77 mmol) and 2,3-dimethylphenyl-1H-imidazol-2-ylmethylamine (358 mg, 1.77 mmol), according to the same procedure used for the preparation of example 1 above.

Workup

  1. customused for the preparation of example 1 above

Sources & evidence

ORD record
ord-518fafbf122644fb84f08ee49076358f
Source dataset
uspto-grants-2007_10
Patent number
US07279497B2

Reaction notes

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