HCID 11065861, compound → HCID 10254747, compound

HRID 1179450Notes

Reaction equation

HRID 1179450 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@@H:9]2[O:10][C@@H:8]2[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][CH2:30][C:31]2[NH:32][CH:33]=[CH:34][N:35]=2)=[CH:25][CH:24]=1>>[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@H:9]([OH:10])[C@@H:8]([N:29]([C:26]2[CH:27]=[CH:28][C:23]([O:22][CH3:21])=[CH:24][CH:25]=2)[CH2:30][C:31]2[NH:35][CH:34]=[CH:33][N:32]=2)[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1

Participants

3

Reactant 2

HCID 11065861HCID 11065861, compoundHCID 59708996N-(4-Methoxyphenyl)-1H-imidazole-2-methanamine

Product 1

HCID 10254747HCID 10254747, compoundYield 86.8%

Procedure

The title compound (446 mg, 86%) was prepared using (2R,3R,4R)-3,4-dihydro-2-dimethoxymethyl-3,4-epoxy-2-methyl-6-nitro-2H-1-benzopyran (300 mg, 1.06 mmol) and 4-methoxyphenyl-1H-imidazol-2-ylmethylamine (216 mg, 1.06 mmol), according to the same procedure used for the preparation of example 1 above.

Workup

  1. customused for the preparation of example 1 above

Sources & evidence

ORD record
ord-3cafad9563e64af6869c0fd8c386f2b7
Source dataset
uspto-grants-2007_10
Patent number
US07279497B2

Reaction notes

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