HCID 11065861, compound → HCID 67421972, compound

HRID 1179453Notes

Reaction equation

HRID 1179453 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@@H:9]2[O:10][C@@H:8]2[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1.[CH:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[NH:30][CH2:31][C:32]1[NH:33][CH:34]=[CH:35][N:36]=1)([CH3:23])[CH3:22]>>[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@H:9]([OH:10])[C@@H:8]([N:30]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[CH:21]([CH3:23])[CH3:22])[CH2:31][C:32]2[NH:36][CH:35]=[CH:34][N:33]=2)[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1

Participants

3

Reactant 2

HCID 11065861HCID 11065861, compoundHCID 61557724HCID 61557724, compound

Product 1

HCID 67421972HCID 67421972, compoundYield 42%

Procedure

The title compound (72 mg, 42%) was prepared using (2R,3R,4R)-3,4-dihydro-2-dimethoxymethyl-3,4-epoxy-2-methyl-6-nitro-2H-1-benzopyran (100 mg, 0.35 mmol) and 2-isopropylphenyl-1H-imidazol-2-ylmethylamine (75 mg, 0.35 mmol), according to the same procedure used for the preparation of example 1 above.

Workup

  1. customused for the preparation of example 1 above

Sources & evidence

ORD record
ord-028967b2dec84795a2e3d4ea2a8ff80b
Source dataset
uspto-grants-2007_10
Patent number
US07279497B2

Reaction notes

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