HCID 11065861, compound → HCID 10413226, compound

HRID 1179455Notes

Reaction equation

HRID 1179455 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@@H:9]2[O:10][C@@H:8]2[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1.[Cl:21]([C:24]1[CH:25]=[C:26]([NH:30][CH2:31][C:32]2[NH:33][CH:34]=[CH:35][N:36]=2)[CH:27]=[CH:28][CH:29]=1)(=O)=O>>[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@H:9]([OH:10])[C@@H:8]([N:30]([C:26]2[CH:27]=[CH:28][CH:29]=[C:24]([Cl:21])[CH:25]=2)[CH2:31][C:32]2[NH:33][CH:34]=[CH:35][N:36]=2)[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1

Participants

2

Reactant 1

HCID 11065861HCID 11065861, compound

Product 1

HCID 10413226HCID 10413226, compoundYield 39%

Procedure

The title compound (337 mg, 39%) was prepared using (2R,3R,4R)-3,4-dihydro-2-dimethoxymethyl-3,4-epoxy-2-methyl-6-nitro-2H-1-benzopyran (500 mg, 1.77 mmol) and 3-chloroxyphenyl-1H-imidazol-2-ylmethylamine (366 mg, 1.77 mmol), according to the same procedure used for the preparation of example 1 above.

Workup

  1. customused for the preparation of example 1 above

Sources & evidence

ORD record
ord-f3e325af6228492491fb820a7f55b2aa
Source dataset
uspto-grants-2007_10
Patent number
US07279497B2

Reaction notes

Loading…