HCID 10967937, compound → HCID 10005740, compound

HRID 1179456Notes

Reaction equation

HRID 1179456 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@:4]1([CH3:18])[C@H:9]2[O:10][C@H:8]2[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1.[Cl:21]([C:24]1[CH:25]=[C:26]([NH:30][CH2:31][C:32]2[NH:33][CH:34]=[CH:35][N:36]=2)[CH:27]=[CH:28][CH:29]=1)(=O)=O>>[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@:4]1([CH3:18])[C@@H:9]([OH:10])[C@H:8]([N:30]([C:26]2[CH:27]=[CH:28][CH:29]=[C:24]([Cl:21])[CH:25]=2)[CH2:31][C:32]2[NH:33][CH:34]=[CH:35][N:36]=2)[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1

Participants

2

Reactant 1

HCID 10967937HCID 10967937, compound

Product 1

HCID 10005740HCID 10005740, compoundYield 52.1%

Procedure

The title compound (280 mg, 35%) was prepared using (2S,3S,4S)-3,4-dihydro-2-dimethoxymethyl-3,4-epoxy-2-methyl-6-nitro-2H-1-benzopyran (450 mg, 1.6 mmol) and 3-chloroxyphenyl-1H-imidazol-2-ylmethylamine (232 mg, 1.1 mmol), according to the same procedure used for the preparation of example 1 above.

Workup

  1. customused for the preparation of example 1 above

Sources & evidence

ORD record
ord-6570187509f14dea82f13ed63070b07d
Source dataset
uspto-grants-2007_10
Patent number
US07279497B2

Reaction notes

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