HCID 11065861, compound → HCID 10007414, compound

HRID 1179457Notes

Reaction equation

HRID 1179457 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@@H:9]2[O:10][C@@H:8]2[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1.[F:21][C:22]([F:38])([F:37])[O:23][C:24]1[CH:29]=[CH:28][C:27]([NH:30][CH2:31][C:32]2[NH:33][CH:34]=[CH:35][N:36]=2)=[CH:26][CH:25]=1>>[CH3:1][O:2][CH:3]([O:19][CH3:20])[C@@:4]1([CH3:18])[C@H:9]([OH:10])[C@@H:8]([N:30]([C:27]2[CH:26]=[CH:25][C:24]([O:23][C:22]([F:38])([F:37])[F:21])=[CH:29][CH:28]=2)[CH2:31][C:32]2[NH:36][CH:35]=[CH:34][N:33]=2)[C:7]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5]1

Participants

3

Reactant 2

HCID 11065861HCID 11065861, compoundHCID 54976452HCID 54976452, compound

Product 1

HCID 10007414HCID 10007414, compoundYield 40.5%

Procedure

The title compound (155 mg, 40%) was prepared using (2R,3R,4R)-3,4-dihydro-2-dimethoxymethyl-3,4-epoxy-2-methyl-6-nitro-2H-1-benzopyran (200 mg, 0.71 mmol) and 4-trifluoromethoxyphenyl-1H-imidazol-2-ylmethylamine (183 mg, 0.71 mmol), according to the same procedure used for the preparation of example 1 above.

Workup

  1. customused for the preparation of example 1 above

Sources & evidence

ORD record
ord-4e32b6667e85408a881205bab0d3d1fc
Source dataset
uspto-grants-2007_10
Patent number
US07279497B2

Reaction notes

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