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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1179535Generated: October 26, 2026

2-Methyl-5-(4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline → 7-Chloro-2-methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline

https://huagongshe.com/reaction/1179535

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-5-(4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinolineHCID 49851902—
Reactant2-(3-Nitrophenyl)ethyl 4-nitrobenzenesulfonateHCID 57444274—
Reactant7-Chloro-2-methyl-5-piperazin-1-ylquinolineHCID 57444275—
Product7-Chloro-2-methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinolineHCID 5744427692%

Reaction Steps

The title compound was prepared in 92% yield using a similar procedure to description D5 starting from 7-chloro-2-methyl-5-(1-piperazinyl)quinoline (D16) and 2-(3-Nitrophenyl)ethyl 4-nitrobenzenesulfonate (D15).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07279481B2
Source datasetuspto-grants-2007_10
ORD IDord-5d997b20eea44312a63fafcfaa862ac7
Source noteuspto-grants-2007_10