Dimethyl-1,3-thiazole-5-carboxylic acid → 2,4-Dimethyl-N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-thiazole-5-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Dimethyl-1,3-thiazole-5-carboxylic acid	HCID 736488	—
Reactant	3-(2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline	HCID 49852105	—
Product	2,4-Dimethyl-N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-thiazole-5-carboxamide	HCID 11306286	68%

Reaction Steps

The title compound was prepared in 68% yield according to the general procedure for the preparation of the amides (Method C) starting from 3-{2-[4-(2-methyl-5quinolinyl)-1-piperazinyl]ethyl}aniline (D6) and 2,4dimethyl-1,3-thiazole-5-carboxylic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07279481B2
Source dataset	uspto-grants-2007_10
ORD ID	ord-a1f19cdbfb834e9c8d591561fd62c89f
Source note	uspto-grants-2007_10